Factors of ferulic acid synthesis by uniform design based on rough set theory
Objective To determine the basic rules between production factors in the drug synthesis,and seek for the optimal method based on rough set theory.Methods Using rough set theory and ferulic acid synthesis as an example,uniform design experiment was used for the pretreatment.The decision table based on rough set was formed to optimize the extraction process.Results In ferulic acid synthesis,the factor level of reaction time and ferulic acid yield showed a linear increase(P＜0.01),the ratio of raw materials,pyridine amount level and ferulic acid yield showed no linear increase(P＞0.05).But when the three factors were at level 7,the test results were the best,with the best combination.Conclusion The rough set theory can be used to analyze the inherent dynamic law between the factors of drug synthesis and the test results,providing reference for the quality optimization of drug synthesis.
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