Establishment and application of drug use evaluation criteria for denosumab
Objective To establish the drug use evaluation(DUE)standard for denosumab in clinical application,and provide reference for its rational use.Methods Based on the domestic and foreign drug instructions of denosumab,relevant guidelines,literatures,diagnosis and treatment standards,the DUE standard was established by Delphi method concerning drug indications,administration process and results.Yidu cloud system was used to evaluate the rationality of drug use among inpatients who received denosumab in a large comprehensive hospital in Xinjiang from January 2022 to September 2023.Results The DUE standard of denosumab was divided into 3 tier 1 indexes,11 tier 2 indexes and 31 tier 3 indexes.Totally 840 inpatients who met the criteria were included.The coincidence rate of medication indication was 77.14％,the coincidence rate of medication process was 16.90％,and the coincidence rate of symptom relief was 66.31％.Totally 84(10％)of adverse drug reactions related to denosumab occurred,and most of them were improved or cured.Irrational usage covered non-standard diagnosis(1.90％),off-label use contraindications(23.21％),unreasonable drug administration frequency(83.1％)and incomplete medical records.Conclusion The DUE standard of denosumab is feasible and scientific.The problems in the treatment of patients with denosumab can be regarded as the focus of intervention,to ensure the safe medications use.
denosumabdrug use evaluationrational drug useDelphi method
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