Research progress in TRPC6-mediated diseases and related small molecule regulators
The canonical transient receptor potential channel 6(TRPC6)is a member of the transient receptor potential ion channel family,which exhibits widespread expression in various organs and tissues throughout the human body and participates in diverse physiological functions.Numerous studies have demonstrated that TRPC6 channels are subject to regulation by multiple factors and directly or indirectly contribute to the pathophysiological processes associated with renal and cardiovascular diseases.Moreover,as research progresses,more small molecule modulators have been identified that can influence the activity or expression of TRPC6,thereby exerting beneficial effects on related diseases.These findings offer a theoretical foundation and potential targets for developing novel therapeutic drugs targeting TRPC6-related diseases.This article provided an overview of the pivotal role of TRPC6 in the development of renal and cardiovascular diseases,and reviewed diseases mediated by TRPC6 as well as their associated small molecule regulators.
万方数据
维普
