Advances in cardiovascular protective effect and mechanism of sesquiterpenoids
Sesquiterpenoids have many structural skeletons and are widely distributed in the nature,with various physiological activities and playing important roles in protecting the cardiovascular system.Sesquiterpenoids mainly improve myocardial hypertrophy,ameliorate myocardial ischaemia,attenuate myocardial infarction,protect against endothelial cell damage and atherosclerosis.These compounds exert cardiovascular protective effects through various pathways,including inhibition of oxidative stress and modulation of related signalling pathways,such as NF-κB,PI3K/Akt,ERK1/2,and TGF-β1/Smad.This paper reviewed the cardiovascular protective effects of these compounds and their mechanism for further development sesquiterpenes.
万方数据
维普
