Progress in the application of zebrafish in pharmacological and toxicological research
As a novel laboratory animal model,zebrafish has short lifecycle,high reproduction rate,rapid embryonic development,and high similarity with genes and mechanism human diseases.These specific physiological advantages enable zebrafish to be widely used in disease research and drug development,as well as drug efficacy and safety evaluation in many pharmaceutical institutions.Zebrafish can be used in drug screening,pharmacokinetics,and safety evaluation.However,there are some limitations in the zebrafish model,such as lack of standardization of experimental techniques and animal standards.This papre reviewed the progress in the application of zebrafish in pharmacological and toxicological research,to provide references for further application of zebrafish in preclinical drug development.
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