Analysis of 1782 case of maternal adverse drug reaction in Foshan
Objective To determine the characteristics and regularity of maternal adverse drug reactions(ADR)in Foshan,and to provide reference for safe and rational drug use.Methods A retrospective study was conducted to collect the data of 1782 cases of maternal ADRs from Foshan Adverse Drug Reaction Monitoring Center from 2012 to 2023.Results Among 1782 ADR cases in maternal,ADR in the puerperium was the most common(48.82％),with the majority ranging 21～35(81.59％)years old.ADRs mainly invovled the skin and subcutaneous diseases,systemic diseases and various reactions at the administration sites and gastrointestinal diseases.The top three drug catgories causing ADRs included reproductive system drugs(38.51％),antimicrobial drugs(27.20％),and electrolytes,acid-base balance and nutrition drugs(10.44％).The main drug type causing serious ADRs was reproductive system drugs.Antimicrobial drugs were the main type causing anaphylactic shock,mainly cephalosporins;anaphylactic shock usually occurred within 30 min,and about 14.81％of maternal had a history of drug allergy.Totally 254 cases of irrational drug use were found in ADR reports,with 31(12.20％)serious ADRs.The drug variety with the highest incidence of serious ADRs caused by irrational use of drugs was antimicrobial drugs.Conclusion We should strengthen the drug monitoring of maternal,especially 30 min before the medication,monitor the ADR of reproductive system drugs and antimicrobial drugs,and the monitor perioperative antimicrobial drugs to reduce irrational medication use.
万方数据
维普
