Objective To design and synthesize derivatives of quercetin-3'-OH with the aim of preliminary screening for quercetin derivatives displaying stronger anti-colon cancer activity.Methods Quercetin was utilized as the lead compound to connect various lengths of alkyl chains at 3'-OH position.Different types of fragment groups were linked via amide or sulfonamide bonds.A series of quercetin derivatives were designed,synthesized,and subjected to anti-tumor activity testing.Results Totally 11 quercetin derivatives QCT-001～QCT-011 were successfully designed and synthesized,with most of the compounds exhibiting good anti-tumor activity.Among them,QCT-009 demonstrated the highest inhibitory activity with an IC50 ranging from 11.25 to 23.25 μmol·L-1.Conclusion The strategy of fragment growth and structural modification at 3'-OH position of quercetin shows promise in enhancing its anti-tumor activity.This study provides an experimental foundation for further research on the synthesis of such compounds.
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