Therapeutic potential of natural Farnesoid X receptor agonists for irritable bowel syndrome with diarrhea
Affected by dietary habits,social and psychological pressure and other factors,the irritable bowel syndrome with diarrhea in China is getting more prevalent.Many patients are accompanied by abnormal bile acid metabolism.Farnesoid X receptor(FXR)is a key receptor involved in the bile acid metabolism and can regulate bile acid synthesis.This article summarized the potential therapeutic effect of natural FXR agonists on irritable bowel syndrome with diarrhea,which mainly included improving clinical symptoms,regulating bile acid metabolism,improving intestinal barrier damage,and regulating intestinal flora.Natural FXR agonists are expected to be potential drugs for irritable bowel syndrome with diarrhea with abnormal bile acid metabolism.
irritable bowel syndrome with diarrheaFarnesoid X receptor agonistbile acid metabolismintestinal barrier injuryintestinal flora
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