Research progress in the mechanism of plant-derived natural products in ameliorating acetaminophen-induced liver injury
Acetaminophen(APAP)is a widely used antipyretic and analgesic drug,but its overdose may lead to acute liver injury or even acute liver failure.Recently,plant-derived natural products have attracted much attention in preventing and treating drug-induced liver injury for their potential multi-target effects,multiple pathways,and low toxicity.This paper reviewed the incidence and mechanisms of APAP-induced liver injury,and the progress in the protective effects of plant-derived natural products against APAP-induced liver damage,to provide a reference for prevention and treatment of APAP-induced liver injury.
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