植物类天然产物改善对乙酰氨基酚致肝损伤作用机制的研究进展
Research progress in the mechanism of plant-derived natural products in ameliorating acetaminophen-induced liver injury
王有根 1杨志慧 2杨秀鸿 3易吉平 3曾明1
作者信息
- 1. 中南大学湘雅公共卫生学院卫生毒理学系,长沙 410013
- 2. 西安交通大学第一附属医院癌症中心,西安 710061
- 3. 湖南省职业病防治院,长沙 410021
- 折叠
摘要
对乙酰氨基酚(APAP)是应用最广泛的解热镇痛药之一,过量服用可导致急性肝损伤,甚至急性肝衰竭.近年来,植物类天然产物因具有多靶点、多途径、低毒性等优点,被广泛用于防治药物性肝损伤的研究.因此,本文对APAP诱导肝损伤的发生情况和相关机制,以及植物类天然产物改善APAP致肝损伤的作用机制研究进行综述,以期为防治APAP致肝损伤提供参考.
Abstract
Acetaminophen(APAP)is a widely used antipyretic and analgesic drug,but its overdose may lead to acute liver injury or even acute liver failure.Recently,plant-derived natural products have attracted much attention in preventing and treating drug-induced liver injury for their potential multi-target effects,multiple pathways,and low toxicity.This paper reviewed the incidence and mechanisms of APAP-induced liver injury,and the progress in the protective effects of plant-derived natural products against APAP-induced liver damage,to provide a reference for prevention and treatment of APAP-induced liver injury.
关键词
植物类天然产物/对乙酰氨基酚/肝损伤Key words
plant-derived natural compound/acetaminophen/liver injury引用本文复制引用
出版年
2024
NETL
NSTL
万方数据