Research progress in the molecular mechanism of natural products against myocardial ischemia/reperfusion injury
The mechanism of myocardial ischemia/reperfusion injury(MIRI)primarily involves oxidative stress,inflammatory response,calcium overload,cell apoptosis,autophagy,and energy metabolism disorders.Natural products have been widely used in the prevention and treatment of cardiovascular and cerebrovascular diseases due to their of low toxicity and multiple targets.To further determine their therapeutic mechanisms for MIRI,this paper comprehensively reviewed the progress in the study of natural products related to the signaling pathways of MIRI.It also discussed the mechanism of natural products against MIRI with network pharmacological analysis.Due to the complex of natural medicines,there is still a long way to go to fully elucidate their molecular mechanisms of alleviating MIRI.
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