首页|MiRNA调控脑缺血/再灌注诱导的自噬信号通路研究进展

MiRNA调控脑缺血/再灌注诱导的自噬信号通路研究进展

扫码查看
原文链接
  • 万方数据
  • 维普
脑卒中时缺血缺氧致脑组织功能损伤,且缺血后脑组织再恢复血液供应时,大量自由基、钙超载等引起脑缺血/再灌注损伤,进一步加重病情.自噬是一种维持细胞内环境稳态的自我保护机制,但过度自噬引起脑组织损伤.MiRNA为小的内源性非编码RNA分子,通过与其靶基因mRNA的3'-UTR中的互补序列结合,导致翻译抑制或mRNA降解,从基因水平上调控多种生理活动.MiRNA不仅直接作用于自噬相关蛋白,还可通过多种信号通路,参与缺血/再灌注诱导的自噬调控.但关于miRNA调控脑缺血/再灌注诱导的自噬信号通路尚缺乏系统性归纳与分析.本文综述了miRNA-124、miRNA-298、miRNA-202-5p、miRNA-142以及miRNA-26b等miRNA通过不同信号通路调控脑缺血/再灌注中的细胞自噬,为脑卒中的自噬研究提供了系统的理论思路.
MiRNA Regulating Autophagy Signaling Pathway Induced by Cerebral Ischemia/Reperfusion
Ischemia and hypoxia cause functional damage to brain tissues during stroke,and when blood supply is re-stored to brain tissues after ischemia,a large number of free radicals and calcium overload cause cerebral ischemia-reper-fusion injury,which further aggravates the condition.Autophagy is a self-protection mechanism that maintains the homeo-stasis of the intracellular environment,but excessive autophagy causes brain tissue damage.MiRNA is a small endogenous non-coding RNA molecule that regulate various physiological activities at the gene level by binding to complementary se-quences in the 3 ′-UTR of its target gene mRNA,leading to translation inhibition or mRNA degradation.MiRNA not only directly acts on autophagy related proteins,but also participates in autophagy regulation induced by ischemia/reperfusion through various signaling pathways.However,there is still a lack of systematic induction and analysis of miRNA regulation of autophagy signaling pathways induced by cerebral ischemia/reperfusion.This article reviews the regulation of cellular au-tophagy during cerebral ischemia/reperfusion by miRNA-124,miRNA-298,miRNA-202-5p,miRNA-142,miRNA-26b and so on through different signaling pathways,providing a systematic and theoretical approach for the study of autoph-agy in stroke.

cerebral ischemia reperfusion injuryMicroRNAautophagysignal pathwayautophagy related pro-teinsregulation

刘筱蔼、罗友根

展开 >

广东食品药品职业学院,广东 广州 510520

江苏医药职业学院盐城市偏瘫康复工程技术研究中心,江苏 盐城 224005

脑缺血/再灌注损伤 微小RNA 自噬 信号通路 自噬相关蛋白 调控

国家自然科学基金江苏省产学研合作项目江苏省双创计划广东省医学科学技术研究基金广东食品药品职业学院自然科学研究项目江苏医药职业学院博士科研启动项目

31660271BY20221030JSSCBS20211166A20201642016YZ00920200010

2024

10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20240004.003

中山大学学报(医学科学版)
中山大学

中山大学学报(医学科学版)

CSTPCD北大核心
影响因子：1.608
ISSN：1672-3554
年,卷(期)：2024.45(1)
  • 5