Effect of Diffuse Glioma with Precentral Gyrus Invasion on Interhemispheric Brain Activation:A Task-based FMRI Study
[Objectives]To explore the effect of diffuse glioma with precentral-gyrus invasion on fMRI activation maps by grasping T-fMRI.[Methods]A total of 56 diffuse glioma patients were divided into precentral-gyrus invasion(PGI:n=21)and precentral-gyrus non-invasion(PGNI:n=35)groups.Three statistical thresholds(P value:10-4,P1;10-6,P2;10-8,P3)were set to obtain the activation maps accordingly(V1,V2 and V3).The interhemispheric and bilat-eral precentral gyrus activation volumes ratios(IAVR and PAVR)were calculated,respectively.The activation volumes[△V1=V1-V2;△V2=V2-V3;△Vn(ipsilateral)/△Vn'(contralateral),n=1,2]within two statistical thresholds and the corresponding interhemispheric ratio was further compared.In addition,the associations of tumor characteristics with IAVR and PAVR were analyzed.[Results]Compared with PGNI,PGI showed significantly decreased IAVR at p1,and the same trends of PAVR in PGI at P1 and P2(P＜0.05).However,neither IAVR nor PAVR showed significant differences at P3.PGI showed significantly lower ratios of △V1/△V1'than PGNI(P=0.02),except for △V2/△V2'.Additionally,within PGI,PAVR was negatively correlated with tumor volume(P=0.043),and the distance from the tumor to the hand-knob was positively correlated with the IAVR and PAVR(P＜0.05).[Conclusion]Diffuse glioma invading eloquent areas tended to affect interhemispheric asymmetry of activation at relatively lower statistical thresholds than diffuse glioma with-out invasion,rather than stricter statistical thresholds.Multiple ranges of statistical thresholds were recommended to ana-lyze T-fMRI.
万方数据
维普
