Effect of Direct-acting Antivirals Treatment on Renal Function Among HCV-infected Patients
[Objective]To explore the effect of direct-acting antiviral treatment on renal function in patients with chronic hepatitis C.[Methods]A total of 123 HCV-infected patients receiving DAAs treatment at the Third Affiliated Hos-pital of Sun Yat-sen University from January 2017 to December 2021 were included in this study.To explore the renal function in patients with chronic hepatitis C treated with direct-acting antivirals,serum creatinine values were collected before,during and after the treatment,which were used to estimate the eGFR by the MDRD equation to assess the changes in renal function.[Results]Of the 123 patients enrolled,67.5%(n=83)were male,and the mean age of participants was(50±11)years old.The mean follow-up period was 24 weeks.Comorbidities included cirrhosis in 26.8%,and diabetes in 10.6%.Meanwhile,11.4%of the cohort had eGFR＜60 mL/(min·1.73 m2),33.3%of the cohort had eGFR 60 to 90 mL/(min·1.73 m2),and 55.3%had eGFR≥90 mL/(min·1.73 m2).No decrease in renal function was seen among all the HCV-infected patients at the end of treatment or the follow-up period after treatment.However,compared with the eG-FR at the baseline,eGFR in CKD2 patients in the follow-up period was improved[(88.65±15.52)mL/(min·1.73 m2)vs(78.12±7.60)mL/(min·1.73 m2),P＜0.001].And 14.6%(n=18)of patients experienced progressive deterioration of re-nal function.Logistic regression analysis showed that diabetes could predict the deterioration of renal function(OR=4.663,P=0.016).[Conclusions]Our study shows renal function is not impair among HCV-infected patients following DAAs treat-ment,and renal function in CKD2 patients have improvements.However,HCV-infected patients with diabetes mellitus are at a high risk of renal impairment and closely monitoring of renal function is still needed.
hepatitis C virusdirect-acting antiviralsHCV treatmentrenal function
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维普
