Effect and Mechanism of N-acetylcysteine in Ischemic Stroke
Ischemic stroke(CIS)refers to ischemic necrosis or softening of localized brain tissue caused by cerebral blood circulation disorders,ischemia and hypoxia.The incidence of CIS is the highest among cerebrovascular diseases.Re-duced supply of oxygen and nutrients leads to severe loss of neurons and deficits in brain function in stroke patients.Devel-oping treatments for ischemic stroke remains an important challenge in clinical medicine.The antioxidant N-acetylcysteine(NAC)is a precursor of glutathione,and evidence from animal models of ischemic stroke and some clinical studies sug-gest that NAC can effectively protect the brain from ischemic damage.In this paper,the mechanism of NAC in CIS is de-scribed from various aspects,such as anti-oxidation,inhibition of inflammation,protection of cerebral nerve and mito-chondrial function,stabilization of arterial plaque and thrombolytic function,aiming to explore the relationship between NAC and CIS in depth from the basic level,and to provide a theoretical basis for the further application of NAC in the pre-vention and treatment of patients with ischemic stroke.
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