首页|基于OCTA构建糖尿病肾脏病临床预测模型

基于OCTA构建糖尿病肾脏病临床预测模型

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[目的]探讨基于光学相干断层扫描血管成像技术(OCTA),筛查糖尿病肾脏病(DKD)高风险人群的临床预测模型.[方法]本研究以567例糖尿病患者为研究对象,在逐步logistic回归分析的基础上,运用随机森林算法筛选纳入建模的指标,构建基于OCTA糖尿病肾脏病临床预测模型.通过受试者工作特征曲线评价模型区分度,通过决策曲线分析评估模型临床有效性.[结果]构建基于OCTA的DKD临床预测模型,ROC曲线下面积为0.878,Bri-er=0.11.[结论]本研究构建了基于OCTA结果进行糖尿病肾脏病临床预测的列线图预测模型,并从多维度验证模型,从而达到早期预警、提前实施干预的目的.
Clinical Prediction Model for Diabetic Kidney Disease Based on Optical Coherence Tomography Angiography
[Objective]To construct and validate a clinical prediction model for diabetic kidney disease(DKD)based on optical coherence tomography angiography(OCTA).[Methods]This study enrolled 567 diabetes patients.The random forest algorithm as well as logistic regression analysis were applied to construct the prediction model.The model discrimina-tion and clinical usefulness were evaluated by receiver operating characteristic curve(ROC)and decision curve analysis(DCA),respectively.[Results]The clinical prediction model for DKD based on OCTA was constructed with area under the curve(AUC)of 0.878 and Brier score of 0.11.[Conclusions]Through multidimensional verification,the clinical pre-diction nomogram model based on OCTA allowed for early warning and advanced intervention of DKD.

optical coherence tomography angiography(OCTA)diabetic kidney disease(DKD)clinical predic-tion modelreceiver operating characteristic curve(ROC)decision curve analysis(DCA)

陆丽娇、徐楠、刘鑫鑫、杜芳芳、郑枞、彭鸿钧、曹明哲、艾诗蓓

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中山大学附属第七医院眼科,广东 深圳 518000

光学相干断层扫描血管成像技术 糖尿病肾脏病 临床预测模型 受试者工作特征曲线 决策曲线分析

2024

中山大学学报(医学科学版)
中山大学

中山大学学报(医学科学版)

CSTPCD北大核心
影响因子:1.608
ISSN:1672-3554
年,卷(期):2024.45(2)
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