Predictive Value of Serum Albumin Levels for Coronary Artery Calcification in Patients with Early Chronic Kidney Disease
[Objective]To explore the correlation between serum albumin levels and coronary artery calcification(CAC)in patients with early-stage chronic kidney disease(CKD),as well as the value of serum albumin levels in predict-ing the incidence and severity of CAC.[Methods]The study included 391 early-stage CKD patients who underwent coro-nary computed tomography angiography(CTA)at Sun Yat-sen Memorial Hospital of Sun Yat-sen University between Jan-uary 2019 and December 2022.Demographic and biochemistry data,as well as the coronary CTA results,were collected.Based on the coronary artery calcification score(CACS),all patients were divided into non-CAC group(CACS=0,n= 184)and CAC group(CACS>0,n=207).All patients were further divided into 3 groups based on the serum albumin lev-els:group A(serum albumin levels<35 g/L,n=30),group B(35 g/L≤serum albumin levels<40 g/L,n=198)and group C(serum albumin levels≥40 g/L,n=163).Univariate and multivariate binary logistic regression analyses were conducted to investigate the association between serum albumin levels and CAC in early-stage CKD patients.Differences in CAC among groups were analyzed by using post-hoc multiple comparisons and ordinal logistic regression model analysis.[Re-sults]Patients with CAC had significantly lower serum albumin levels than those without CAC(P<0.05).There was a nega-tive correlation between serum albumin levels and CACS in early-stage CKD patients(P<0.01),as serum albumin de-creased in levels,CAC increased in severity.[Conclusions]Our study shows that early-stage CKD patients with lower se-rum albumin levels have a higher incidence of CAC.Low serum albumin level is an independent risk factor for CAC pro-gression.
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