Low BMI is Associated with Poor OI-IUI Outcomes in Patients with Unexplained Primary Infertility
[Objective]To evaluate the effect of women's body mass index(BMI)on pregnancy outcomes of ovulation induction intrauterine insemination(OI-IUI)in patients with unexplained primary infertility.[Methods]The study includ-ed 764 OI-IUI cycles from January 2016 to December 2022 in reproductive center of Sun Yat-sen Memorial Hospital.Ac-cording to BMI,patients were divided into three groups:low BMI(BMI<18.5 kg/m2),normal BMI(18.5 kg/m2≤BMI＜23.0 kg/m2),and high BMI(BMI≥23.0 kg/m2).Comparison of clinical data and pregnancy outcomes was performed be-tween the groups.Logistic regression was used to analyze the association between BMI and live birth rate.[Results]From the low BMI group to the high BMI group,the HCG positive rate(7.08%,9.74%,13.19%),clinical pregnancy rate(5.51%,7.91%,13.19%),and live birth rate(4.72%,6.90%,12.50%)increased.Among them,the live birth rate of the high BMI group was significantly higher than that of the low BMI group and the normal BMI group,with a statistically significant difference(P=0.034).While the early miscarriage rate(14.28%,10.26%,5.26%)decreased from the low BMI group to the high BMI group.The binary logistic regression analysis revealed that BMI was an independent factor in live birth,and high BMI resulted in a better live birth rate than low BMI(OR=3.15,95%CI=1.191-8.329,P=0.021).[Con-clusion]Low BMI is associated with poor OI-IUI outcomes in patients with unexplained primary infertility.These patients are encouraged to gain weight in a healthy manner.
unexplained infertilitybody mass indexintrauterine inseminationlive birthclinical outcomes
万方数据
维普
