首页|针刺调节BDNF/TrkB信号通路改善中枢神经系统疾病的研究进展

针刺调节BDNF/TrkB信号通路改善中枢神经系统疾病的研究进展

扫码查看
原文链接
  • 万方数据
  • 维普
BDNF/TrkB信号通路作为神经元生长、发育和突触可塑性的关键调节器,广泛参与中枢神经系统疾病的发生发展,如缺血性脑卒中、阿尔茨海默病、帕金森病和脊髓损伤等.研究表明针刺能调节BDNF/TrkB信号通路的活性,对以上疾病具有显著的治疗潜力,其作用机制与参与突触结构重塑,抑制神经细胞凋亡,促进神经发生和突触再生等有关.本文综述了BDNF/TrkB相关信号通路在中枢神经系统疾病中的作用以及针刺对该通路的调控机制,以期为临床治疗提供新思路.未来研究应深入探究针刺对BDNF/TrkB信号通路的精准调控,以开发更高效安全的治疗策略.
Research Progress of Acupuncture in Improving Central Nervous System Diseases by Regulating BDNF/TrkB Signaling Pathway
As a key regulator of neuronal growth,development and synaptic plasticity,BDNF/TrkB signaling path-way is widely involved in the occurrence and development of central nervous system diseases,such as ischemic stroke,Al-zheimer's disease,Parkinson's disease and spinal cord injury.Studies have shown that acupuncture can regulate the activi-ty of BDNF/TrkB signaling pathway,and has significant therapeutic potential for these diseases.Its mechanism of action is related to participating in synaptic remodeling,inhibiting neuronal apoptosis,and promoting neurogenesis or synaptic re-generation.This article reviews the role of BDNF/TrkB signaling pathway in central nervous system diseases and the regula-tion mechanism of acupuncture on this pathway,in order to provide new ideas for clinical treatment.Future studies should further explore the precise regulatory mechanism of acupuncture on BDNF/TrkB signaling pathway in order to develop more efficient and safe treatment strategies.

acupunctureBDNF/TrkB signaling pathwaycentral nervous system diseasesischemic strokeAlzheimer's diseaseParkinson's diseasespinal cord injurymechanism of action

栗文静、白艳杰

展开 >

河南中医药大学,河南 郑州 450046

河南中医药大学第一附属医院,河南 郑州 450000

针刺 BDNF/TrkB信号通路 中枢神经系统疾病 缺血性脑卒中 阿尔茨海默病 帕金森病 脊髓损伤 作用机制

河南省中医药科学研究专项重点课题河南省中医药传承与创新人才工程(仲景工程)中医药学科拔尖人才河南省科技攻关计划河南省卫健委国家中医临床研究基地科研专项河南省中医药拔尖人才培养项目专项课

20-21ZY1009CZ0237-082221023105292022JDZX0052022ZYBJ07

2024

10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20240617.002

中山大学学报(医学科学版)
中山大学

中山大学学报(医学科学版)

CSTPCD北大核心
影响因子：1.608
ISSN：1672-3554
年,卷(期)：2024.45(4)