Research Progress on Estrogen and Candidalysin in Vulvovaginal Candidiasis
Candida albicans(CA)is the predominant cause of vulvovaginal Candidiasis(VVC).Increasing circulatory estrogen levels such as pregnancy,the use of oral contraceptives,and hormone replacement therapy predispose women to VVC.Estrogen affects the progression of VVC by regulating the growth of CA hyphae,the immune response of the innate immune cells and epithelial cells of host vaginal,but the mechanism is unclear till now.Candidalysin(CL)is a fungal peptide toxin critical for mucosal infection and plays an important role in the CA infection.CL was encoded by ECE1,which was regulated by estrogen.This article reviews the correlation between estrogen,CL,and VVC for further clarifying the role of estrogen and CL in the pathogenesis of VVC.
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