Advances in the Mechanism of Action of Hydrogel in Repairing Spinal Cord Injury
Spinal cord injury(SCI)is a severe central nervous system disease with poor prognosis,and the resulting severe sensory,motor or autonomic dysfunction greatly reduces patients'quality of life.Although considerable progress has been made in the treatment and care of SCI,the clinical efficacy and prognosis of SCI are not satisfactory due to the inability of drugs to be delivered directly to the site of SCI through the blood-spinal cord barrier and the fact that the local microenvironment after SCI is not conducive to the survival,differentiation,and proliferation of implanted stem cells.Due to its excellent mechanical properties,plasticity,and good biocompatibility and biodegradability,hydrogel can be used as a delivery system for loading stem cells or drugs,providing a favorable environment and controlling their release,and as a biological scaffold to support and guide axonal regeneration,which can effectively improve the therapeutic effect of spinal cord injury.This paper mainly reviews the classification and functional properties of hydrogels,and further discusses the research progress of hydrogels in SCI repair to improve the inhibitory microenvironment of spinal cord injury,promote nerve regeneration,promote angiogenesis,and promote the repair of the blood-spinal cord barrier,with the aim of providing a theoretical basis for the clinical application of hydrogels in the treatment of SCI as well as for exploring and developing future spinal cord regeneration strategies.
spinal cord injuryhydrogelmechanism of actionmicroenvironmentnerve regeneration
万方数据
维普
