Application and Prospect of Tumor-associated Macrophages in Anti-tumor Immunotherapy
Anti-tumor immunotherapy has made remarkable breakthroughs in the past few decades,demonstrating unprecedented efficacy in certain types of cancer,but the emergence of drug resistance not only limits the long-term effectiveness of immunotherapy,but can also lead to cancer recurrence and progression. Therefore,how to overcome immunotherapy resistance has become a key problem to be solved in current cancer research. Tumor-associated macrophages (TAM) have gradually become an important option and potential therapeutic target in cancer treatment in recent years. Their unique role in the tumor microenvironment (TME) makes them promising in anti-tumor therapy. For the study of TAM in cancer treatment,the current exploration includes multiple aspects and challenges. These studies not only involved the mechanism of action of TAM in different tumor types,but also covered the interaction of TAM with other immune cells and signaling pathways in TME. Therefore,this article reviews the application of TAM in anti-tumor immunotherapy,aiming to provide reference for future related studies.
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