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雄黄毒性研究进展

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雄黄具有解毒杀虫、燥湿祛痰、截疟的功效,适用于多种病症,临床主要用于治疗痈肿疔疮、蛇虫咬伤、虫积腹痛、惊痫及疟疾等.现代研究表明雄黄对血液系统疾病、恶性淋巴系统疾病以及实体瘤等具有良好的治疗作用,尤其对白血病的疗效颇为显著.雄黄作为一种有毒的含砷矿物药,若使用不当,其毒性也不容忽视.雄黄发挥治疗作用或毒性作用的成分为可溶性砷,包括无机砷和有机砷.雄黄具有中枢神经系统毒性、肝脏毒性及遗传毒性作用,合理配伍可以降低雄黄的毒性.炮制对雄黄的毒性有影响,水飞法炮制的雄黄毒性更低,目前也有研究者采用微生物转化、纳米技术等新技术对雄黄毒性进行研究.本文通过对雄黄毒性进行综述,以期为雄黄的安全合理用药提供理论依据.
Review on the toxicity of realgar
Realgar has the effects of detoxification and insecticide,dampness and expectorant and malaria,and is suitable for a variety of diseases,and is mainly used for the treatment of carbuncle boils,snake bites,abdominal pain,epilepsy and malaria.Modern studies have shown that realgar has a good therapeutic effect on hematologic diseases,malignant lymphatic diseases and solid tumors,especially for leukemia.As a toxic arsenic-containing mineral drug,realgar can not be ignored if used improperly.Realgar is a component of soluble arsenic that has a therapeutic or toxic effect,including inorganic arsenic and organic arsenic.Realgar has central nervous system toxicity,hepatotoxicity and genotoxicity,and reasonable compatibility can reduce the toxicity of realgar.Processing has an impact on the toxicity of realgar,and the toxicity of realgar processed by the water fly method is even lower,and some researchers have used new technologies such as microbial transformation and nanotechnology to study the toxicity of realgar.In this paper,the toxicity of realgar is reviewed,in order to provide a theoretical basis for the safe and rational use of realgar.

realgartoxicityarsenicAs4S4As2O3

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中国人民解放军联勤保障部队第九四三医院,甘肃武威 733000

雄黄 毒性 As4S4 As2O3

2024

中兽医医药杂志
中国农业科学院中兽医研究所

中兽医医药杂志

影响因子:0.203
ISSN:1000-6354
年,卷(期):2024.43(2)
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