Preparation and in vitro dissolution of matrine amorphous solid dispersion
The purpose was to improve sustained-release performance of matrine(MAT)and prolong the release time in vitro.In this study,matrine amorphous solid dispersion(MAT-ASD)was prepared by ball milling method with MAT as the target drug and ethyl cellulose(EC)as the carrier,and was characterized by powder X-ray diffraction(PXRD),differential scanning calorimetry(DSC)and Fourier transform infrared spectroscopy(FT-IR),so as to investigate its release characteristics in vitro.The results showed that MAT-ASD was successfully prepared using this method(the ratio of drug to carrier was 1∶9).There were no crystal characteristic peaks of matrine in PXRD,and no crystal endothermic peak of matrine in DSC,and FT-IR showed that there was an interaction between matrine and EC,which may have resulted in intermolecular hydrogen bonds.The results of in vitro dissolution showed that the cumulative dissolution rate of MAT reached almost 100%within 0.25 h,while the cumulative dissolution rate of MAT-ASD was only 56.29%.At 6 h,the cumulative dissolution rate of MAT-ASD was 95.22%.The results showed that MAT-ASD was successful prepared by ball milling with EC as the carrier,which could effectively prolong the in vitro release time of matrine and lay a foundation for the development of matrine sustained release preparations.
国家科技期刊平台
NSTL
万方数据
