Effects of different types of salt on the chemical composition of processing Fructus Toosendan-Fructus Foeniculi drug pair
This study aims to investigate the effects of different types of salt on the chemical composition of processing Fructus Toosendan-Fructus Foeniculi drug pair,providing a reference for selecting salt for processing excipients.Salts produced by different manufacturers and regions were used to process Fructus Toosendan-Fructus Foeniculi(1∶1)drug pair according to the 2020 edition of the Chinese Pharmacopoeia.HPLC method was used to determine the content of toosendanin,isotoosendanin,α-pinene and transanethole in the processed products,and the content differences were compared by SPSS method.The results showed that among the 5 salt roasted samples(S1-S5),there were no significant difference in the content of α-pineneand and transanethole(P>0.05),while the content of toosendanin and isotoosendanin in S2 sample was significantly higher(P<0.01 or P<0.05)than that in other group samples.There was no significant difference in the content of toosendanin and isotoosendanin in other group samples(P>0.05).The results indicate that the five salts have similar effects on the content of α-pineneand and transanethole in Fructus Toosendan-Fructus Foeniculi.After Y2 salt(low sodium salt)processing,the content of toosendanin and isotoosendanin in the sample is higher than that in other salt roasted samples.Based on literature research and considerations of drug efficacy and safety,ordinary salts other than low sodium salts are selected as the processing excipients for Fructus Toosendan-Fructus Foeniculi drug pair.
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