Sterile insect technology (SIT) is a novel strategy for biological control in the field by releas-ing sterile insects to reduce pest populations. To apply insect infertility technology to the prevention and control of the globally invasive pest Spodoptera frugiperda,this review provides a detailed explanation of the mechanism and status of insect infertility technology. It summarized the global use of SIT in pest control,including its principles,modes of action,and successful cases against various insects. In addi-tion,this review provides a detailed analysis of the functional role of an important target gene for SIT,doublesex. Furthermore,it explores the potential of pest control through the release of insects carrying lethal genes based on CRISPR/Cas9 gene editing system,providing a theoretical basis for promoting the utilization of SIT for pest control.