目的 探讨中性粒细胞与白蛋白比值(neutrophil to albumin ratio,NAR)、中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、单核细胞与淋巴细胞比值(monocyte to lymphocyte ratio,MLR)、血小板与淋巴细胞比值(platelet to lymphocyte ratio,PLR)及全身免疫炎症指数(systemic immune-inflammation index,SII)在精神分裂症中的临床意义.方法 选取 2019 年 1 月至 2021 年 6 月南宁市社会福利医院收治的 215 例精神分裂症患者纳入精神分裂症组,选取同期于该院健康体检者 113 人纳入对照组.比较两组研究对象的 NAR、NLR、MLR、PLR、SII,并分析其与精神分裂症临床症状评分的相关性及服用抗精神病药物后的变化.结果 精神分裂症组患者的NAR、NLR、PLR、MLR、SII水平均显著高于对照组(P<0.05).Spearman相关性分析结果显示,NAR、NLR、SII与阳性症状评定量表评分均呈负相关(P<0.05).精神分裂症组患者抗精神病药物治疗后,各炎症指标均有所下降,但NAR、MLR仍显著高于对照组(P<0.05).结论 精神分裂症存在免疫炎症激活状态,抗精神病药物治疗后NAR、MLR水平下降不明显,可能与精神分裂症症状的持续存在有一定关系.
Clinical significance analysis of peripheral blood inflammation indexes in schizophrenia
Objective To investigate the clinical significance of neutrophil to albumin ratio(NAR),neutrophil to lymphocyte ratio(NLR),monocyte to lymphocyte ratio(MLR),platelet to lymphocyte ratio(PLR)and systemic immune-inflammation index(SII)in schizophrenia.Methods A total of 215 patients with schizophrenia admitted to Nanning Social Welfare Hospital from January 2019 to June 2021 were included in schizophrenia group,and 113 healthy people who underwent physical examination in hospital during the same period were included in control group.NAR,NLR,MLR,PLR,SII of two groups were compared,and the correlation between them and the clinical symptom score of schizophrenia and changes after taking antipsychotic drugs were analyzed.Results The levels of NAR,NLR,PLR,MLR and SII in schizophrenia group were significantly higher than those in control group(P<0.05).Spearman correlation analysis showed that NAR,NLR,SII and scale for the assessment of positive symptom scores were negatively correlated(P<0.05).After treatment with antipsychotic drugs,all inflammatory indexes were decreased in schizophrenia group,but NAR and MLR were still significantly higher than those in control group(P<0.05).Conclusion There is an active state of immune inflammation in schizophrenia,and the levels of NAR and MLR do not decrease significantly after treatment with antipsychotic drugs,which may be related to the persistence of schizophrenia symptoms.
SchizophreniaNeutrophil to albumin ratioMonocyte to lymphocyte ratioSystemic immune-inflammation index
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