Meta analysis of the efficacy and safety of dienogest in the treatment of adenomyosis
Objective To evaluate the efficacy and safety of dienogest in the conservative treatment of adenomyosis(AM).Methods The relevant randomized controlled trials were searched by computer from domestic and foreign electronic bibliographic databases to August 2023.Risk of bias tool was used to evaluate the literature quality,and RevMan 5.4 software was used for analysis.Results A total of 654 patients with AM were included in 9 randomized controlled trials.338 patients received dienogest for 3 to 6 months.Meta-analysis results showed that the total effective rate of dienogest in the treatment of adenomyosis(OR=6.70,95％CI:1.84-24.42,P=0.004)and serum carbohydrate antigen 125(CA125)reduction(MD=-6.89,95％CI:-12.84-0.93,P=0.02),uterine volume(MD=-26.49,95％CI:-37.86-15.12,P<0.00001),quality of life questionnaire score(MD=6.12,95％CI:4.76-7.47,P<0.00001),the difference was statistically significant.Pain improvement(MD=-0.14,95％CI:-2.19-1.92,P=0.90),endometrial thickness(MD=-0.54,95％CI:-3.66-2.59,P=0.74),the difference was not statistically significant.The overall incidence of adverse reactions(OR=0.51,95％CI:0.12-2.18,P=0.37)and the incidence of irregular vaginal bleeding(OR=1.98,95％CI:0.25-15.59,P=0.52),the difference was not statistically significant.Conclusion Dienogest improves overall response rates,reduces uterine volume in certain degree,relieves subjective symptoms,and improves quality of life in patients with adenomyosis.
万方数据
维普
