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直肠癌术后吻合口漏相关危险因素分析

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目的 探讨直肠癌术后发生吻合口漏(anastomotic leakage,AL)的相关危险因素.方法 回顾性分析 2019 年 1 月至 2021 年 12 月于临沂市人民医院诊治的 392 例直肠癌患者的临床资料.根据是否发生AL将其分为AL组(n=17)和非AL组(n=375).收集患者的相关临床资料,采用二元Logistic回归分析直肠癌患者术后发生AL的危险因素.结果 AL组患者的体质量指数(body mass index,BMI)≥25kg/m2、术前存在肠梗阻、有围手术期输血史、手术时长≥3h及术后白细胞计数≥10×109/L的占比均显著高于非AL组(P<0.05);二元Logistic回归分析结果显示,BMI≥25kg/m2、术前存在肠梗阻、手术时长≥3h均为直肠癌患者术后发生AL的独立危险因素(P<0.05).结论 肥胖、术前存在肠梗阻、手术时间长的直肠癌患者术后发生AL的风险较高,应针对以上危险因素采取相应预防措施,以降低AL的发生率及提升患者的生存质量.
Analysis of risk factors related to anastomotic leakage after rectal cancer surgery
Objective To investigate the risk factors related to postoperative anastomotic leakage(AL)of rectal cancer.Methods The clinical data of 392 patients with rectal cancer diagnosed and treated in Linyi People's Hospital from January 2019 to December 2021 were retrospectively analyzed.They were divided into AL group(n=17)and non-AL group(n=375)according to whether AL occurred.The relevant clinical data of patients were collected,and the risk factors of postoperative AL in rectal cancer patients were analyzed by binary Logistic regression.Results The proportion of body mass index(BMI)≥25kg/m2,preoperative intestinal obstruction,perioperative blood transfusion history,operation duration≥3h and postoperative white blood cell count≥10×109/L in AL group were significantly higher than those in non-AL group(P<0.05).Binary Logistic regression analysis showed that BMI≥25kg/m2,preoperative intestinal obstruction,and operation duration≥3h were all independent risk factors for postoperative AL in rectal cancer patients(P<0.05).Conclusion Patients with rectal cancer who are obese,have preoperative intestinal obstruction,and have long operation duration have a higher risk of postoperative AL.Corresponding preventive measures should be taken according to the above risk factors to reduce the incidence of AL and improve the quality of life of patients.

Rectal cancerAnastomotic leakageRisk factor

程辉、郭明晓

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锦州医科大学临沂市人民医院研究生培养基地,山东临沂 276000

临沂市人民医院普外科,山东临沂 276000

直肠癌 吻合口漏 危险因素

2024

中国现代医生
中国医学科学院

中国现代医生

影响因子:1.571
ISSN:1673-9701
年,卷(期):2024.62(4)
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