首页|麝香保心丸对微血管心绞痛血管内皮功能的影响

麝香保心丸对微血管心绞痛血管内皮功能的影响

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目的 测定原发性微血管心绞痛(primarymicrovascular angina,PMVA)患者血浆血管性假血友病因子(von Willebrand factor,vWF)水平评价血管内皮功能,观察给予麝香保心丸治疗前后vWF水平的改变.方法 明确诊断PMVA的患者 69例,采用随机数字表法分为常规治疗组 33 例和麝香保心丸组 36 例,比较两组患者治疗前后vWF水平.结果 常规治疗组治疗前vWF(50.93±32.98)μg/L治疗后vWF(49.65±35.12)μg/L,麝香保心丸组治疗前vWF(27.45±25.02)μg/L治疗后vWF(17.37±15.68)μg/L.治疗后vWF下降值麝香保心丸组(10.08±16.47)μg/L较常规治疗组(1.28±12.37)μg/L更明显,P<0.05.结论 麝香保心丸具有血管内皮保护功能,PMVA患者能从治疗中获益.
Effect of Shexiangbaoxin Pill on vascular endothelial function in patients with primary microvascular angina
Objective The plasma von Willebrand factor(vWF)level in patients with primary microvascular angina(PMVA)were measured to evaluate the vascular endothelial function of the patients.The change of vWF level in patients after the treatment with Shexiangbaoxin Pill were observeg.Methods Totally 69 patients who were definitely diagnosed as PMVA,They were randomly divided into conventional treatment group(33cases)and ShexiangBaoxin Pill group(36cases).The plasma vWF levels of the two groups were measured before and after treatment.Results The level of vWF before treatment in conventional treatment group was(50.93±32.98)μg/L.The level of vWF before treatment in ShexiangBaoxin Pill group was(27.45±25.02)μg/L.The level of vWF in conventional treatment group after treatment was(49.65±35.12)μg/L.The level of vWF after treatment in ShexiangBaoxin Pill group was(17.37±15.68)μg/L.The difference of vWF decrease in Baoxin Pill group after treatment(10.08±16.47)μg/L,was lower than that in conventional treatment group(1.28±12.37)μg/L,the difference is significant(P<0.05).Conclusion Shexiang Baoxin Pill has the function of protecting vascular endothelium,and PMVA patients can benefit from treatment.

ShexiangBaoxin PillPrimary microvascular anginaVascular endothelial functionVon Willebrand factor

黄琪、隋向前、蒋凤春、何武剑、裴德安、王士生、胡永宾

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杭州市红十字会医院心内科,浙江杭州 310003

杭州市红十字会医院内分泌科,浙江杭州 310003

麝香保心丸 原发性微血管心绞痛 血管内皮功能 血管性假血友病因子

中国中西医结合学会和黄药业科研基金浙江省中医药科技计划浙江省医药卫生科技计划浙江省医药卫生科技计划

20190062020ZA0832019KY5102020KY220

2024

中国现代医生
中国医学科学院

中国现代医生

影响因子:1.571
ISSN:1673-9701
年,卷(期):2024.62(8)
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