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妊娠期A型肉毒毒素暴露对妊娠结局的影响

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目的 回顾性分析妊娠期A型肉毒毒素(botulinum toxin A,BTX-A)暴露孕妇的妊娠结局,为临床医生指导妊娠期女性安全用药提供参考.方法 调查 2017 年 1 月至 2023 年 3 月在杭州市妇产科医院用药咨询门诊就诊的妊娠期或妊娠前 3 个月内BTX-A暴露孕妇的妊娠结局.结果 共收集 17 例妊娠期或妊娠前 3 个月内BTX-A暴露孕妇案例.8 例已知妊娠结局,其中 1 例胎儿存在出生缺陷,出生缺陷发生率为 12.5%;其余 9 例均要求早期人工流产.结论 妊娠期暴露于BTX-A很可能是安全的,但仍需进一步的研究证实.
Effect of botulinum toxin A exposure during pregnancy on pregnancy outcome
Objective To retrospectively analyze the pregnancy outcome of pregnant women exposed to botulinum toxin A(BTX-A)during pregnancy,so as to provide experience for clinicians to guide safe drug use in pregnant women.Methods To investigate the pregnancy outcome of pregnant women exposed to BTX-A during pregnancy or the last three months before pregnancy who visited the medication consultation clinic of Hangzhou Women's Hospital from January 2017 to March 2023.Results A total of 17 pregnant women exposed to BTX-A during pregnancy or the last three months before pregnancy were included in this study.Specifically,8 cases had known pregnancy outcomes,among which 1 case had birth defect with the ratio accounting for 12.5%,while the remaining 9 cases required early induced abortion.Conclusion Exposure to BTX-A during pregnancy is probably safe,but further studies are needed.

PregnancyBotulinum toxin APregnancy outcome

蔡宇庭、周晓媚

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杭州市妇产科医院药剂科,浙江杭州 310008

妊娠期 A型肉毒毒素 妊娠结局

浙江省医药卫生科技计划

2019KY529

2024

中国现代医生
中国医学科学院

中国现代医生

影响因子:1.571
ISSN:1673-9701
年,卷(期):2024.62(9)
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