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桃花汤治疗溃疡性结肠炎疗效的系统评价

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目的 评价桃花汤治疗溃疡性结肠炎的临床疗效.方法 检索中国知网、万方数据知识服务平台、维普网、中国生物医学数据库、PubMed、Web of science、Cochrane library,筛选文献并采集文献相关信息,使用Review Manager 5.3评价偏倚风险并对各疗效指标进行系统评价.结果 检索获得 546 篇文献,经过剔重和筛选最终纳入 16 篇文献.Meta分析显示临床总有效率:RR=1.19,95%CI:1.14~1.24,P<0.001,结肠镜积分:MD=-0.61,95%CI:-1.11~-0.11,P=0.020,肿瘤坏死因子-α:MD=-22.18,95%CI:-36.70~-7.66,P=0.003,C反应蛋白:MD=-10.85,95%CI:-30.48~8.77,P=0.280,不良反应发生率:RR=0.40,95%CI:0.24~0.65,P<0.001.结论 桃花汤治疗溃疡性结肠炎在临床总有效率、结肠镜积分、肿瘤坏死因子-α及不良反应发生率方面优于对照组.
Systematic review of therapeutic effect of taohua decoction on ulcerative colitis
Objective To evaluate the clinical efficacy of Taohua Decoction in treating ulcerative colitis.Methods Searching CNKI,Wanfang,Weipu,China Biomedical Database,PubMed,Web of science,and Cochrane library,Screening literature and collecting literature related information.Using Review Manager 5.3 to evaluate the risk of bias and systematically evaluate efficacy indicators.Results A total of 546 articles were retrieved,and 16 were eventually included after censoring and screening.Meta analysis showed that total clinical effective rate:RR=1.19,95%CI:1.14-1.24,P<0.001.Colonoscopy score:MD=-0.61,95%CI:-1.11--0.11,P=0.02.Tumor necrosis factor(TNF)-α:MD=-22.18,95%CI:-36.70--7.66,P=0.003.C-reactive protein:MD=-10.85,95%CI:-30.48-8.77,P=0.28.Incidence of adverse reactions:RR=0.40,95%CI:0.24-0.65,P<0.001.Conclusion The total clinical effective rate,colonoscopy score,TNF-α and incidence of adverse reactions of Taohua Decoction in treating ulcerative colitis was superior to that in the control group.There was no significant difference between Taohua Decoction and the control group in reducing C-reactive protein.

Taohua decoctionUlcerative colitisSystematical reviewMeta analysis

陆艾阳子、高卉、沈浩然、郭秋红

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河北中医药大学药学院,河北石家庄 050000

无锡市中医医院中医科,江苏无锡 2141003

河北省中医院,河北肾病二科,河北石家庄 050100

桃花汤 溃疡性结肠炎 系统评价 Meta分析

河北省教育厅高等学校科学技术研究项目河北省省属高校青年教师科研能力提升项目

QN202309720230530

2024

中国现代医生
中国医学科学院

中国现代医生

影响因子:1.571
ISSN:1673-9701
年,卷(期):2024.62(11)
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