目的 探讨体素内不相干运动扩散加权成像(intravoxel incoherent motion in body diffusion-weighted imaging,IVIM-DWI)序列中慢速表观扩散系数(slow apparent diffusion coefficient,ADCslow)、快速表观扩散系数(fast apparent diffusion coefficient,ADCfast)和灌注分数(perfusion fraction,f)值在青年人群腰椎间盘早期退变定量分析中的预测价值.方法 采用IVIM-DWI技术作为磁共振定量成像,对温州市人民医院 120 例下腰部疼痛患者(596 个腰椎间盘)中的测量腰椎间盘的ADCslow、ADCfast和f值,基于Pfirrmann分级标准分为三组.采用SPSS 20.0 统计学软件进行数据分析.结果 ADCfast值区分各分组腰椎间盘具有统计学意义:正常组vs.早期退变组曲线下面积(area under the curve,AUC)=0.766,敏感度 64.2%,特异性 78.5%;正常组vs.中晚期退变组AUC=0.822,敏感度 67.9%,特异性 91.3%;早期退变组vs.中晚期退变组AUC=0.797,敏感度 62.1%,特异性 92.1%.ADCslow值区分各分组腰椎间盘具有统计学意义:正常组vs.早期退变组AUC=0.707,敏感度 83.6%,特异性 61.0%;正常组vs.中晚期退变组AUC=0.701,敏感度 84.5%,特异性 58.6%;早期退变组vs.中晚期退变组AUC=0.668,敏感度 86.6%,特异性 51.0%.f值不能区分各分组腰椎间盘.结论 IVIM-DWI序列的ADCslow与ADCfast在区分青年人群腰椎间盘早期退变有一定的准确性与特异性,可为临床早期治疗提供可靠依据.
Quantitative analysis of early lumbar disc degeneration in young adults by intravoxel incoherent motion in body diffusion-weighted imaging
Objective To explore the predictive value of slow apparent diffusion coefficient(ADCslow),fast apparent diffusion coefficient(ADCfast)and perfusion fraction(f)value of intravoxel incoherent motion in body diffusion-weighted imaging(IVIM-DWI)sequence in early lumbar disc degeneration in young people.Methods The IVIM-DWI technique was used as quantitative magnetic resonance imaging for 120 patients(596 lumbar intervertebral discs)with lower back pain included in Wenzhou People's Hospital.The ADCslow,ADCfast and f values of all lumbar intervertebral discs were measured,and then they were divided into 3 groups according to the Pfirrmann grading standard.SPSS 20.0 statistical software was used to analyze the data.Results The ADCfast value has statistical significance in distinguishing the lumbar intervertebral discs of each group:The area under the curve(AUC)of the normal group vs.the early degenerative group was 0.766,with a sensitivity of 64.2%and a specificity of 78.5%;The AUC of the normal group vs.the mid to late stage degenerative group was 0.822,with a sensitivity of 67.9%and a specificity of 91.3%;The AUC of the early degeneration group vs.the middle and late stage degeneration group was 0.797,with a sensitivity of 62.1%and a specificity of 92.1%.The ADCslow value has statistical significance in distinguishing the lumbar intervertebral discs of each group:AUC=0.707 in the normal group vs.the early degenerative group,with a sensitivity of 83.6%and a specificity of 61.0%;The AUC of the normal group vs.the mid to late stage degenerative group was 0.701,with a sensitivity of 84.5%and a specificity of 58.6%;The AUC of the early degeneration group vs.the middle and late stage degeneration group was 0.668,with a sensitivity of 86.6%and a specificity of 51.0%.The f value cannot distinguish between different groups of lumbar intervertebral discs.Conclusion ADCslow and ADCfast of IVIM-DWI sequence have certain accuracy and specificity in distinguishing the early degeneration of lumbar intervertebral disc in young people,which provides a reliable basis for early clinical treatment.
国家科技期刊平台
NSTL
万方数据
