Median effective dose of propofol or cyclopofol combined with alfentanil in inhibiting body movement response during induced abortion
Objective To explore the median effective dose of propofol or cyclopofol combined with alfentanil in inhibiting body movement response during induced abortion.Methods From October 2021 to April 2022,patients aged 18-35 years,body mass index(BMI)18-28 kg/m2,American Society of Anesthesologists(ASA)I or II,fetal age<10 weeks,first pregnancy or no history of vaginal delivery were selected for elective painless induced abortion in Gynecological Surgery Center of the Second Hospital of Jiaxing.Patients were divided into 2 groups using a random number table method:propofol group(group P)and cyclopofol group(group C).During anesthesia induction,intravenous injection of alfentanil was followed by administration of propofol or cyclopofol with a dose set by the modified sequential method.If the patient had involuntary limb movement during surgery and affected the operation of the operator and needed additional anesthetic drugs,it was judged as a positive reaction,and intravenous propofol or cyclopofol 0.5mg/kg or 0.1mg/kg was added,and the next patient's propofol or cyclopofol was increased by a dose gradient.Conversely,the next patient was given a dose gradient of 0.5mg/kg propofol or 0.1mg/kg cyclopofol,respectively.Probit regression analysis was used to calculate the median effective dose(ED50),95%effective dose(ED95)and corresponding confidence interval(CI)of propofol and cyclopofol.Results The ED50(95%CI)and ED95(95%CI)of propofol in group P were 1.815(1.315-2.319)mg/kg and 2.901(2.368-6.447)mg/kg,respectively.The ED50(95%CI)and ED95(95%CI)of cyclopofol in group C were 0.381(0.279-0.484)mg/kg and 0.613(0.501-1.344)mg/kg,respectively,and the equivalent ratio of the two was 4.76(4.71-4.79).Conclusion The potency of ciprofol in inhibiting movement response during induced abortion is greater than that of propofol.
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