Predictive value of AMH and GDF9 levels in serum and follicles on fertility of infertile patients
Objective To explore predictive value of serum and follicular anti-Müllerian hormone(AMH)and growth differentiation factor 9(GDF9)levels on fertility in infertile patients.Methods From April 2020 to February 2023,200 infertile patients admitted to Huzhou Hospital of Traditional Chinese Medicine Affiliated Zhejiang Chinese Medicine University were selected as study group.According to number of antral follicles and maximum diameter of ovarian plane,they were divided into good fertility group(n=114)and poor fertility group(n=86).In addition,132 healthy women in same period were selected as control group.General and clinical data of subjects were collected,serum AMH and GDF9 levels were compared between study group and control group;serum and follicular fluid AMH and GDF9 levels were compared between good fertility group and poor fertility group;influencing factors of fertility of infertile patients were analyzed;correlation between serum AMH and GDF9 levels and follicle-stimulating hormone(FSH),luteinizing hormone(LH)and estradiol levels of infertile patients were analyzed by Pearson correlation analysis;and predictive value of serum AMH and GDF9 levels on fertility of infertile patients was analyzed by receiver operating characteristic curve.Results Compared with control group,serum AMH and GDF9 levels in study group were significantly decreased(P<0.05).Compared with good fertility group,AMH and GDF9 levels in serum and follicles of poor fertility group were significantly decreased(P<0.05).Compared with good fertility group,FSH level,proportion of infertility years more than two years,proportion of ovulation promotion number more than two times,pulsatility index of ovarian interstitial artery and resistance index inpoor fertility group were significantly increased,number of eggs obtained,number of sinus follicles,peak systolic velocity,LH and estradiol levels were significantly decreased(P<0.05).Serum AMH and GDF9 levels in infertility patients were negatively correlated with FSH level(r<0,P<0.05),and positively correlated with LH and estradiol levels(r>0,P<0.05).Serum and follicular AMH,serum and follicular GDF9,number of retrieved eggs,FSH,LH,number of antral follicles and maximum systolic blood flow velocity were factors that affect fertility of infertile patients(P<0.05).Area under the curve of fertility of infertility patients diagnosed by AMH and GDF9 combined was significantly greater than that predicted by AMH and GDF9 alone(P<0.05).Conclusion Serum and follicular fluid AMH and GDF9 levels of infertile patients are related to their fertility,and serum AMH and GDF9 levels have certain predictive value for fertility.
万方数据
维普
