Establishment of reference interval for GSP and HbA1c in healthy pregnant women at 24-28 weeks of gestation in Korla region
Objective To establish the reference interval of glycosylated serum protein(GSP)and glycosylated hemoglobin(HbA1c)in healthy pregnant women in Korla region at 24-28 weeks of gestation,so as to provide a basis for clinical screening of gestational diabetes mellitus(GDM).Methods A total of 795 pregnant women who underwent obstetric examination and delivery in Korla Hospital of the Second Division of Xinjiang Production and Construction Corps were selected as the study objects.According to the results of oral glucose tolerance test at 24-28 weeks,pregnant women were divided into healthy study group(n=627)and GDM group(n=168).The pregnant women in health study group were divided into appropriate age group(age<35 years,n=491)and elderly group(age≥35 years,n=136)according to the age of delivery.A total of 131 healthy non-pregnant women were selected as control group.The levels of GSP and HbA1c in each group were detected,and the reference interval was established by percentile method(P2.5-P97.5).Receiver operating characteristic(ROC)curve was used to evaluate the efficacy of GSP and HbA1c in screening GDM.Results There were statistically significant differences in GSP and HbA1c in appropriate age group,elderly group and control group(P<0.05).There was no significant difference in GSP and HbA1c between appropriate age group and elderly group(P>0.05).The reference interval of GSP and HbA1c was 188.15-257.75 μmol/L and 4.50%-5.70%in healthy pregnant women at 24 to 28 weeks of gestation,respectively.ROC curve results showed the area under the curve of GSP and HbA1c screening GDM alone was 0.803 and 0.708,respectively.Conclusion The reference interval of GSP and HbA1c were 188.15-257.75 μmol/L and 4.5%-5.7%in 24 to 28 weeks of gestation of healthy pregnant women in Kuerla region,respectively,and GSP and HbA1c had great application value in screening GDM population.
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