Clinical value of serum vaspin in diagnosis of nontraumatic osteonecrosis of femoral head
Objective To investigate the clinical value of visceral adipose tissue-derived serine protease inhibitor(vaspin)level in the diagnosis of nontraumatic osteonecrosis of femoral head(NONFH).Methods A total of 77 NONFH patients hospitalized in Linyi People's Hospital from November 2022 to May 2023 were included in necrotic group,and 76 healthy persons in our hospital during the same period were included in normal group.The general data of two groups were compared,and serum vaspin levels of patients with different clinical characteristics in necrotic group were compared.Receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of serum vaspin in NONFH.Results The serum vaspin level in necrotic group was significantly lower than that in normal group(P<0.05).Serum vaspin levels in patients with bilateral hip disease were significantly lower than those in patients with unilateral hip disease(P<0.05).Serum vaspin levels in patients with femoral head collapse was significantly lower than that in patients without femoral head collapse(P<0.05).The serum vaspin level decreased with the increase of Association Research Circulation Osseous(ARCO)stage(P<0.05).Serum vaspin level was negatively correlated with ARCO stage and visual analogue scale score(P<0.05),but positively correlated with Harris hip score(P<0.05).ROC curve showed that the area under the curve of serum vaspin for NONFH was 0.868(95%CI:0.813-0.923,P<0.001),sensitivity was 82.9%,specificity was 75.3%.Conclusion Vaspin can be used as a potential serum marker for the diagnosis of NONFH.With the progression of NONFH,the serum vaspin level tends to decrease.
VaspinNontraumatic osteonecrosis of femoral headDiagnostic marker
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