The clinical significance of serum E2 and LDL-C levels in postmenopausal atherosclerotic ischemic stroke
Objective To study the clinical significance of estradiol(E2)and low-density lipoprotein cholesterol(LDL-C)in postmenopausal atherosclerotic ischemic stroke(IS).Methods A total of 110 postmenopausal patients with atherosclerotic IS who were treated in the First People's Hospital of Huzhou from March 2022 to March 2023 were included in study group,110 postmenopausal patients with non-atherosclerotic IS were included in disease control group,and 110 healthy postmenopausal women were included in health group.The serum E2 and LDL-C were compared among all groups.The relationship between serum E2 and LDL-C levels and the degree of disease in postmenopausal patients with atherosclerotic IS was analyzed.To explore the risk factors that influence the degree of disease in postmenopausal patients with atherosclerotic IS.Results There were significant differences in serum E2 and LDL-C levels among three groups(P<0.05),including E2 level in healthy group>disease control group>study group,and LDL-C level in healthy group<disease control group<study group.Serum E2 in moderate and severe group was significantly lower than that in light group,LDL-C was significantly higher than that in light group(P<0.05).Serum E2 was negatively correlated with National Institutes of Health stroke scale(NIHSS)score and LDL-C(P<0.05),and LDL-C was positively correlated with NIHSS score(P<0.05).Logistic regression analysis showed that age,NIHSS score,degree of carotid artery stenosis,C-reactive protein,lipoprotein-associated phospholipase A2,E2 and LDL-C were risk factors for the degree of postmenopausal atherosclerotic IS disease(P<0.05).Conclusion The decrease of serum E2 level and the increase of LDL-C level in postmenopausal patients with atherosclerotic IS are related to the severity of patient's disease and are risk factors leading to the exacerbation of patient's disease.
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