Hsa-miR-1293 positively regulates SLC3A2,a disulfide death gene and promotes the development of lung adenocarcinoma
Objective To analyse the gene expression profile microarrays of lung adenocarcinoma patients by bioinformatics methods,to study the mechanisms affecting the development of lung adenocarcinoma,and to explore new therapeutic targets for lung adenocarcinoma.Methods The mRNA and miRNA expression data were downloaded from The Cancer Genome Atlas database,key genes were screened by R language and survival analysis and verified by the survival module of the database,and high-expression pathway enrichment analysis was performed for prognostic related genes.Finally,the correlation between key genes and immune cells was analyzed.Results The key disulfide death gene SLC3A2 and key nuclear activation miRNA(hsa-miR-1293)were identified by screening.SLC3A2 was positively correlated with hsa-miR-1293,and the higher the expression,the worse the prognosis of lung adenocarcinoma patients.The most relevant enrichment pathway for SLC3A2 is aminoacyl transfer RNA biosynthesis.SLC3A2 was positively correlated with 4 kinds of differential immune cells and negatively correlated with 4 kinds of differential immune cells.Conclusion Hsa-miR-1293 positively regulates the expression of SLC3A2,a disulfide death gene,to promote the occurrence and development of lung adenocarcinoma,which may provide ideas for developing new therapeutic targets for lung adenocarcinoma.
国家科技期刊平台
NSTL
万方数据
