Clinical effect of ginkgo leaf extract and armillariella mellea powders oral solution on the treatment of coronary heart disease combined with depression and its impact on immune function
Objective To investigate the clinical effect of ginkgo leaf extract and armillariella mellea powders oral solution on the treatment of coronary heart disease complicated with depression and its impact on immune function.Methods A total of 124 patients with coronary heart disease combined with depression admitted to Jinhua Hospital of Traditional Chinese Medicine and Cixi Seventh People's Hospital from July 2019 to July 2023 were randomly divided into control group and observation group,with 62 cases in each group.The control group received conventional treatment,while the observation group received additional treatment with ginkgo leaf extract and armillariella mellea powders oral solution on this basis.After 8 weeks of treatment,inflammatory factors,immune function,quality of life and depression scores were compared between two groups.Results After treatment,the levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-8(IL-8)and CD8+in two groups were significantly lower than before treatment,while the levels of CD3+,CD4+and CD4+/CD8+were significantly higher than before treatment(P<0.05).The levels of CRP,TNF-α,IL-8 and CD8+in observation group were significantly lower than those in control group,while the levels of CD3+,CD4+and CD4+/CD8+were significantly higher than those in control group(P<0.05).After treatment,the scores of Seattle angina questionnair(SAQ)in all dimensions in both groups were significantly higher than before treatment(P<0.05),and the scores of SAQ in all dimensions in observation group were significantly higher than those in control group(P<0.05).After treatment,the Hamilton depression scale score of observation group was significantly lower than that of control group[(9.26±1.58)points vs.(12.87±1.89)points,t=11.538,P<0.001].Conclusion Ginkgo leaf extract and armillariella mellea powders oral solution can inhibit the inflammatory response and improve the symptoms of depression in patients with coronary heart disease and improve the immune function and quality of life.
国家科技期刊平台
NSTL
万方数据
