卡瑞利珠单抗致免疫性肝损伤的临床特征分析
Clinical analysis of immune liver injury induced by camrelizumab
张聪丽 1汪佳兵1
作者信息
- 1. 台州市立医院药剂科,浙江台州 318000
- 折叠
摘要
目的 探讨卡瑞利珠单抗致免疫性肝损伤的病例特点,为临床安全用药提供参考.方法 根据关键词检索并筛选数据库建库至 2023 年 8 月发表的卡瑞利珠单抗致免疫性肝损伤的个案报道,提取数据并进行分析.结果 通过筛选得到 12篇文献,共 12 例患者,其中男 7 例,女 5 例,年龄 43～76 岁,平均(62.92±10.19)岁;多在用药 1 个月内发生免疫性肝损伤.原患疾病均为恶性肿瘤,主要用法用量为 200mg,1 次/3 周,静脉滴注;主要肝损伤级别为 3 级肝损伤.经停药和对症治疗后,症状好转 3 例(25.00%),痊愈 5 例(41.67%),未愈 4 例(33.33%).结论 卡瑞利珠单抗可致免疫性肝损伤,严重者可致死;因此要加强卡瑞利珠单抗的临床合理使用,提高对免疫相关不良事件的认知,重视其引起的免疫性肝损伤.
Abstract
Objective To investigate the case characteristics of immune liver injury induced by camrelizumab,and to provide reference for clinical safety of drug use.Methods According to keywords,the case reports of immune liver injury induced by camrelizumab published from the establishment of the database to August 2023 were retrieved and screened,and the data were extracted and analyzed.Results A total of 12 literatures were selected,involving 12 patients,including 7 males and 5 females.Among them,age 43-76 years old,the average age was(62.92±10.19)years old,and most of them developed immune liver injury within 1 month.The primary diseases were all malignant tumors,and the main dosage of camrelizumab was 200mg intravenously,once every 3 weeks;The main immune liver injury was grade 3.After drug withdrawal and corresponding symptomatic treatment,the symptoms improved in 3 cases(25.00%),recovered in 5 cases(41.67%),and did not recover in 4 cases(33.33%).Conclusion Camrelizumab can cause immune liver injury,which can lead to death in severe cases.Therefore,clinical rational use of camrelizumab should be strengthened,the awareness of immune-related adverse events should be improved and pay attention to the immunological liver injury caused by camrelizumab.
关键词
卡瑞利珠单抗/免疫检查点抑制剂/免疫性肝损伤/免疫相关不良事件/回顾性分析Key words
Camrelizumab/Immune checkpoint inhibitors/Immunologic liver injury/Immune-related adverse events/Retrospective analysis引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据