Anaesthetic effect of low-dose esketamine compound ciprofol in painless induced abortion and its effect on postoperative negative emotions
Objective To explore the anesthetic effect of low-dose esketamine combined with ciprofol in painless induced abortion and its effect on postoperative negative emotions.Methods A total of 100 pregnant women scheduled for elective painless induced abortion at the Gynecological Surgery Center of the Second Hospital of Jiaxing from July to November 2023 were selected as study subjects.Using the random number table method,they were divided into control group and observation group,with 50 cases in each group.The control group received intravenous injection of 10 μg/kg alfentanil and 0.4 mg/kg ciprofol for induction,while the observation group received intravenous injection of 0.3 mg/kg esketamine,10 μg/kg alfentanil and 0.4 mg/kg ciprofol for induction.Adverse reaction rates and changes in heart rate(HR),mean arterial pressure(MAP),and percutaneous arterial oxygen saturation(SpO2)at different time points were observed in both groups.Additionally,the consumption of ciprofol,induction time,operation time,awakening time,orientation recovery time,and the degree of uterine contraction pain were evaluated in both groups.The emotional states of the women in both groups were recorded one day before surgery,the first day after surgery,and the third day after surgery.Results The incidence rates of hypotension,hypoxemia,respiratory depression,and body movement in observation group were significantly lower than those in control group,ciprofol consumption in observation group was significantly less than that in control group,and the induction time,awakening time,and orientation recovery time in observation group were significantly shorter than those in control group(P＜0.05).At T1,HR,MAP,and SpO2 of observation group were significantly higher than those of control group(P＜0.05).From T2 to T3,HR and MAP of observation group were significantly higher than those of control group(P＜0.05).The visual analog scale scores at awakening,30 minutes after awakening,and 60 minutes after awakening in observation group were significantly lower than those in control group(P＜0.05).The self-rating anxiety scale and self-rating depression scale scores of observation group on the first and third days after surgery were significantly lower than those of control group(P＜0.05).Conclusion Low-dose esketamine combined with ciprofol can significantly reduce the incidence of perioperative adverse reactions,alleviate postoperative pain,maintain a positive emotional state,and accelerate postoperative recovery.It is a safe and effective anesthetic strategy.
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