目的 探究天冬氨酸转氨酶和血小板比率指数(aspartate aminotransferase-to-platelet ratio index,APRI)与妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)的相关性.方法 选取安徽医科大学附属巢湖医院产科于2021年9月至2023年3月收治的70例ICP孕妇作为病例组,选择同期70名健康孕妇作为对照组.采用回顾性研究方法,收集并分析两组孕妇分娩前1周的一般资料及实验室资料,并用t检验进行两组间的比较.运用Pearson相关系数法分析APRI与总胆汁酸(total bile acid,TBA)相关性;Logistic回归分析APRI与ICP的关系,采用受试者操作特征(receiver operating characteristic,ROC)曲线评估APRI在ICP中的应用价值.结果 ICP组的APRI(1.1±1.2)高于对照组(0.2±0.1),差异有统计学意义(P＜0.05).重度ICP组的APRI(1.9±2.2)与轻度ICP组(0.9±0.7)比较,差异无统计学意义(P＞0.05).在ICP组中,APRI与TBA呈正相关(r=0.657,P＜0.05).Logistic回归分析结果表明,APRI不是ICP发生的独立影响因素(P＞0.05).APRI 的曲线下面积(area under the curve,AUC)为 0.870(P＜0.05).结论 APRI 与 ICP 的发生及其发展有一定的相关性,而对ICP的病情评估未显示出确定价值.
Study on the correlation between aspartate aminotransferase-to-platelet patio index and intrahepatic cholestasis of pregnancy
Objective To explore the correlation between aspartate aminotransferase-to-platelet ratio index(APRI)and intrahepatic cholestasis of pregnancy(ICP).Methods A total of 70 pregnant women with ICP who were admitted to the Department of Obstetrics of ChaoHu Hospital of Anhui Medical University from September 2021 to March 2023 were selected as the case group,and 70 healthy pregnant women were selected as the control group.A retrospective study was conducted to collect and analyze the general data and laboratory data of the two groups in the week before delivery.The t-test was used to compare all data between the two groups.Pearson correlation coefficient method were used to analyze the relationship between APRI and total bile acid(TBA),Logistic regression were used to analyze the relationship between APRI and ICP,and the application value of APRI in the diagnosis of ICP was evaluated by receiver operating characteristic(ROC)curve.Results The APRI in the ICP group(1.1±1.2),which was significantly higher than that in the control group(0.2±0.1),and the difference was statistically significant(P＜0.05).The APRI in the severe ICP group was(1.9±2.2),which was not significantly different from 0.9±0.7 in the mild ICP group(P＞0.05).In the ICP group,APRI was positively correlated with serum total bile acids(TBA)(r=0.657,P＜0.05).Logistic regression analysis showed that APRI was not an independent influencing factor for the occurrence of ICP(P＞0.05).ROC curve analysis showed that the area under the curve(AUC)of APRI for the diagnosis of ICP was 0.870(P＜0.05).Conclusion APRI has a certain correlation with the occurrence and development of ICP,but the evaluation of ICP has not shown value.
Intrahepatic cholestasis of pregnancyAspartate aminotransferase to platelet ratio index ratioLiver function
万方数据
维普
