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不孕年限对30岁以下育龄女性FET结局的影响

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目的 探讨不孕年限对30岁以下育龄女性冻融胚胎移植(frozen-thawed embryo transfer,FET)结局的影响.方法 回顾性分析生殖中心540例FET周期,根据临床妊娠与否,分临床妊娠组和非临床妊娠组;再按患者不孕年限分为四组:A组(1~2年)、B组(3~4年)、C组(5~6年)和D组(7~8年),分析比较各组的基础资料、临床妊娠结局的差异.结果 各组间基础资料比较,年龄差异有统计学意义(P<0.05),其余均差异无统计学意义;C组的临床妊娠率(33.93%)和胚胎着床率(25%)均最低,但只有临床妊娠率的差异有统计学对意义(P<0.05);四组间的早期流产率差异无统计学意义(P>0.05).结论 不孕年限对30岁以下育龄女性FET的临床妊娠率有影响,但并不是随着不孕年限时间越长影响越显著.
Influence of years of infertility on FET outcomes in women of reproductive age under 30 years of age
Objective To investigate the influence of infertility duration on the outcomes of frozen-thawed embryo transfer(FET)in women under 30 years old.Methods A retrospective analysis was conducted on 540 FET cycles at reproductive center.The cycles were categorized into clinical pregnancy and non-clinical pregnancy groups based on the occurrence of clinical pregnancy.Furthermore,patients were stratified into four groups based on infertility duration:Group A(1-2 years),Group B(3-4 years),Group C(5-6 years),and Group D(7-8 years).Differences in baseline characteristics and clinical pregnancy outcomes among the groups were analyzed.Results Baseline characteristics showed statistical significance only in age differences among the groups(P<0.05),with no other significant differences.The clinical pregnancy rate(33.93%)and embryo implantation rate(25%)in group C were the lowest,but only the difference in clinical pregnancy rate was statistically significant(P<0.05).Early miscarriage rates did not show significant differences among the four groups.Conclusion Infertility duration has a discernible impact significant impact on clinical pregnancy rate of FET in women under 30 years old.However,the effect does not linearly increase with longer infertility duration.

Frozen-thawedembryotransferClinical pregnancy rateImplantation rateEarly miscarriage rate

杜娟、张艳茹、刘兰香

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无锡市人民医院生殖医学科,江苏无锡 214023

中国人民解放军联勤保障部队第九〇四医院生殖中心,江苏无锡 214007

冻融胚胎移植 临床妊娠率 着床率 早期流产率

2024

中国现代医生
中国医学科学院

中国现代医生

影响因子:1.571
ISSN:1673-9701
年,卷(期):2024.62(20)