Association between subclinical hypothyroidism and diabetic retinopathy
Objective To investigate the association between subclinical hypothyroidism(SCH)and diabetic retinopathy(DR).Methods A total of 481 patients with type 2 diabetes mellitus(T2DM)were enrolled in this study from our hospital during January 2019 to March 2022.Patients were divided into no-DR group(n=327),non-severe DR group(n=92)and severe DR group(n=62)according to whether they had DR and the severity of DR.The general data and biochemical indexes were compared among the groups.Spearman correlation analysis was used to evaluate the correlation between DR severity and related clinical indicators.Logistic regression analysis was performed to identify risk factors for odds of DR and severe DR.Results Thyroid stimulating hormone(TSH)was higher(P＜0.05),while free thyroxine(FT4)was lower in non-severe DR group than in no-DR group(P＜0.05).Systolic blood pressure(SBP),diastolic blood pressure(DBP)and serum creatinine(Scr)were higher(P＜0.05),while free triiodothyronine(FT3)and FT4 were lower in severe DR than in no-DR group(P＜0.05).Spearman correlation analysis showed that DR severity was positively correlated with SBP,DBP,duration of diabetes,low-density lipoprotein cholesterol(LDL-C),Scr and TSH(r=0.213,0.142,0.251,0.100,0.159,0.110,P＜0.05)and negatively correlated with FT3 and FT4(r=-0.103,-0.133,P＜0.05).Logistic regression analysis showed that SBP,duration of diabetes ≥ 10years,LDL-C,Scr,TSH＞4.20mIU/L,FT4 were the influencing factors for DR,and SBP,Scr and TSH＞4.20mIU/L were the influencing factors for severe DR.Conclusion SCH is not only a risk factor for DR,but also a risk factor for severe DR.
Type 2 diabetes mellitusDiabetic retinopathySubclinical hypothyroidismThyroid stimulating hormone
万方数据
维普
