Distribution characteristics and drug resistance analysis of carbapenem-resistant enterobacteriaceae in a tertiary hospital
Objective By analyzing the prevalence pattern and drug resistance of carbapenem-resistant enterobacteriaceae(CRE)infections in our hospital,we aim to provide the basis and suggestions for infection prevention and control as well as clinical management in large general hospitals.Methods A retrospective method was used to select 609 CRE strains isolated from hospitalized patients in our hospital from 2019 to 2022,and analyze their specimen sources,distribution of pathogenic bacteria,departmental distribution and drug resistance.Results A total of 6656 strains of Enterobacteriaceae and 609 strains of CRE were detected in the four years,with Klebsiella pneumoniae predominating(354 strains,58.13％),followed by Enterobacter inguinale(82 strains,13.46％)and Escherichia coli(77 strains,12.65％),and the department with the most detected CREs was the intensive care unit(ICU)(44.50％),followed by the Department of Burn Repair(13.79％),Department of Cardiac and Major Vascular Surgery(8.87％)and Department of Oncology(6.4％),and the sources of specimens were sputum(46.96％),secretions(15.60％),urine(13.30％),and blood(8.7％)in that order.The drug sensitivity results showed that the CRE strains had resistance rates＞50％to the rest of the clinically used antimicrobial drugs,except for tigecycline,polymyxin and minocycline,which were sensitive(1.31％,0.56％and 7.22％),and amikacin,fosfomycin,as well as cotrimoxazole,which had a lower resistance rate(23.65％,35.14％and 35.96％).Conclusion The overall trend of CRE detection rate in this hospital from 2019-2022 was increasing,and most of them showed multiple resistance to clinically used antibiotics,attention should be paid to strengthen the rational use of antimicrobial drugs and increase the supervision of bacterial resistance to curb the wide spread of CRE.
万方数据
维普
