中国现代医生2024,Vol.62Issue(21) :16-20.DOI:10.3969/j.issn.1673-9701.2024.21.004

非结核分枝杆菌肺病患者的临床特征及治疗转归相关因素分析

Analyses on clinical characteristics and related factors of treatment outcomes in patients with nontuberculous mycobacterial pulmonary disease

周秋菊 黄小芬 蔡莺莺
中国现代医生2024,Vol.62Issue(21) :16-20.DOI:10.3969/j.issn.1673-9701.2024.21.004

非结核分枝杆菌肺病患者的临床特征及治疗转归相关因素分析

Analyses on clinical characteristics and related factors of treatment outcomes in patients with nontuberculous mycobacterial pulmonary disease

周秋菊 1黄小芬 1蔡莺莺1
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作者信息

  • 1. 浙江省台州医院检验科,浙江台州 318050
  • 折叠

摘要

目的 分析台州市非结核分枝杆菌肺病(nontuberculous mycobacterial pulmonary disease,NTM-PD)患者的临床特征及治疗转归相关因素,为NTM-PD的管理和诊治提供参考依据.方法 回顾性分析于2016年1月至2021年12月在浙江省台州医院确诊的167例NTM-PD患者的临床特征.比较分析83例鸟分枝杆菌复合群肺病(Mycobacterium avium complex pulmonary disease,MAC-PD)患者治愈组和失败组在临床特征上的差异.结果 167例NTM-PD患者中检测到的主要为MAC-PD,占94.6%,其中88例得到治疗,治愈率47.7%.与治愈组比较,失败组患者在体质量指数(body mass index,BMI)≤18.5kg/m2、抗酸涂片阳性、合并结核病史、有纤维空洞和未规范治疗等方面差异有统计学意义(P<0.05).结论 台州市NTM-PD患者以MAC-PD最为常见,BMI≤18.5kg/m2、抗酸涂片阳性、合并结核病史、有纤维空洞和未规范治疗的MAC-PD患者的治疗难度更大.

Abstract

Objective By analyzing the clinical characteristics and related factors of treatment outcomes in patients with nontuberculous mycobacterial pulmonary disease(NTM-PD)in Taizhou,this study provided reference for the management,diagnosis and treatment of NTM-PD.Methods Clinical characteristics of 167 patients with NTM-PD isolated in Taizhou Hospital of Zhejiang Province from January 2016 to December 2021 were retrospectively analyzed.The differences in clinical characteristics were compared between cured group and failed group of 83 cases with Mycobacterium avium complex pulmonary disease(MAC-PD).Results MAC-PD was the most common species among the 167 cases of NTM-PD,accounting for 94.6%,88 patients were treated.The cure rate was 47.7%.Compared with cured group,the patients in failed group had statistical differences in body mass index(BMI)≤ 18.5kg/m2,acid-fast bacilli smear-positive,combined with previous pulmonary tuberculosis,imaging with fibrous-cavernous type and unstandardized medication(P<0.05).Conclusion MAC-PD is the most common among NTM-PD patients in Taizhou.BMI ≤ 18.5kg/m2,acid-fast bacilli smear-positive,combined with previous pulmonary tuberculosis,imaging with fibrous-cavernous type and unstandardized medication of MAC-PD were more difficult to treat.

关键词

非结核分枝杆菌/非结核分枝杆菌肺病/鸟分枝杆菌复合群肺病/治疗转归/不良反应

Key words

Nontuberculous mycobacteria/Nontuberculous mycobacterial pulmonary disease/Mycobacterium avium complex pulmonary disease/Treatment outcomes/Adverse reaction

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基金项目

浙江省医药卫生科技计划项目(2020KY1056)

出版年

2024
中国现代医生
中国医学科学院

中国现代医生

影响因子:1.571
ISSN:1673-9701
参考文献量5
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