目的 观察A激酶相互作用蛋白1(A kinase interacting protein 1,AKIP1)在宫颈癌组织及癌旁组织中的表达情况,分析其与宫颈癌患者临床病理特征及预后的相关性.方法 选取2016年1月至2018年12月聊城市第二人民医院收治的88例宫颈癌患者作为研究对象,免疫组化染色检测宫颈癌组织和癌旁组织的AKIP1表达,根据染色结果评分判定AKIP1表达阴阳性,x2检验分析AKIP1表达情况与患者临床病理特征的相关性;通过Kap1an-Meier曲线分析AKIP1对宫颈癌预后的影响.结果 与癌旁组织相比,宫颈癌组织中的AKIP1阳性表达显著增高(P＜0.05);肿瘤直径≥4cm、肿瘤低分化、发生淋巴结转移及FIGO分期Ⅱ～Ⅲ期患者,AKIP1阳性表达率显著高于肿瘤直径＜4cm、肿瘤中高分化、未发生淋巴结转移及FIGO分期I期患者,差异有统计学意义(P＜0.05);Kaplan-Meier结果提示,与AKIP1阴性表达患者相比,阳性表达患者总体生存率显著降低(x2=5.162,P＜0.05).结论 AKIP1表达与宫颈癌患者较差的临床病理特征相关,可能是影响宫颈癌患者预后的生物学标志物.
Relationship between AKIP1 and clinicopathological features and prognosis of cervical cancer
Objective To observe the expression of A kinase interacting protein 1(AKIP1)in cervical cancer and analyze the correlation between AKIP1 and clinicopathological features and prognosis.Methods A total of 88 patients with cervical cancer admitted to the Second People's Hospital of Liaocheng from January 2016 to December 2018 were selected for the study.The expression of AKIP1 was detected by immunohistochemical staining,and its expression was judged to be negative or positive according to the score of staining results.The relationship between AKIP1 expression and clinicopathological features was analyzed by x2test;Kaplan-Meier curve was used to analyze the effect of AKIP1 on the prognosis of cervical cancer.Results Compared with the para-cancer tissues,the expression of AKIP1 was significantly increased in cervical cancer(P＜0.05);Patients with tumor diameter ≥4 cm,low differentiation,lymph node metastasis and FIGO stageⅡ-Ⅲ,the positive rate of AKIP1 was significantly higher than that of patients with tumor diameter＜4 cm,high differentiation,no lymph node metastasis and FIGO stage I,the difference is statistically significant(P＜0.05);Kaplan-Meier analysis showed that the survival rate of AKIP1 positive patients was significantly lower than that of AKIP1 negative patients(x2=5.162,P＜0.05).Conclusion The expression of AKIP1 is correlated with poor clinicopathologic features in patients with cervical cancer,and may be a biological marker affecting the prognosis of patients with cervical cancer.
Cervical cancerA kinase interacting protein 1Clinicopathological featuresPrognosisImmunohistochemistry
万方数据
维普
