首页|外用皮炎方治疗表皮生长因子受体络氨酸激酶抑制剂相关性皮疹的临床疗效观察

外用皮炎方治疗表皮生长因子受体络氨酸激酶抑制剂相关性皮疹的临床疗效观察

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  • 国家科技期刊平台
  • NETL
  • NSTL
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目的 通过外用皮炎方治疗表皮生长因子受体络氨酸激酶抑制剂(epidermal growth factor receptor tyrosine kinase inhibitor,EGFR-TKIs)相关性皮疹,观察其临床疗效及安全性.方法 采用随机数字表将 EGFR-TKIs 相关性皮疹患者60 例分为治疗组和对照组,每组 30 例,治疗组给予外用皮炎方外涂皮疹处,每日 2 次,14d为 1 个疗程.对照组给予夫西地酸乳膏外涂皮疹处,每日两次,14d为 1 个疗程,观察并记录两组皮疹分级、瘙痒分级、生活质量评分变化情况及不良事件情况,同时在治疗前、治疗结束后 24h检测两组炎症因子:白介素(interleukin,IL)-6、IL-1β、超敏C反应蛋白的水平.结果 经治疗后,治疗组的皮疹分级、瘙痒分级、生活质量评分均较对照组下降(P<0.05).治疗组超敏C反应蛋白、IL-6、IL-1β均较治疗前下降(P<0.05);与对照组比较,超敏C反应蛋白、IL-6、IL-1β均下降,差异有统计学意义(P<0.05).治疗过程中,未发生与皮炎方、夫西地酸乳膏相关不良事件.结论 外用皮炎方治疗 EGFR-TKIs相关性皮疹临床疗效显著,可有效降低炎症因子的水平,且安全性高值得临床推广.
Observation of the clinical efficacy of external application of piyan formula in treating EGFR-TKIs-related rash
Objective To observe the clinical efficacy and safety of external application of Piyan Formula in treating epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKIs)-related rashes.Methods Sixty cases of EGFR-TKIs-related rash patients were randomly allocated into either a treatment group or a control group.The treatment group received external application of Piyan Formula to the rash area twice daily for 14 days.The control group received external application of fucidic acid cream to the rash area twice daily for 14 days.Changes in rash grading,itching grading,quality of life scores and adverse event were observed and recorded in both groups.At the same time,levels of hypersensitive C-reactive protein,interleukin(IL)-6,and IL-1β were measured before treatment and 24 hours after treatment.Results After treatment,the rash severity,itching severity,and quality of life scores were notably lower in the treatment group compared to the control group(P<0.05).The levels of hypersensitive C-reactive protein,IL-6,and IL-1β exhibited a significant decrease compared to their pre-treatment values.(P<0.05).Compared with the control group,the levels of hypersensitive C-reactive protein,IL-6,and IL-1β decreased in the treatment group,with statistically significant differences(P<0.05).No adverse events related to Piyan Formula or fucidic acid cream occurred during the treatment process.Conclusion External application of Piyan Formula in treating EGFR-TKIs-related rashes shows significant clinical efficacy,can effectively reduce the levels of inflammatory factors,and has high safety,thus warranting clinical promotion.

TopicalPiyan formulaEGFR-TKIs-related rashClinical efficacyInflammation

符磊、张慧、林天东、姜靖雯、李梅娇、王鹏、陈浪、黄剑秋、林少妃

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海南省中医院皮肤科,海南海口 570203

海南省中医院肿瘤科,海南海口 570203

海南省中医院国医大师林天东工作室,海南海口 5702031

外用 皮炎方 EGFR-TKIs相关性皮疹 临床疗效

海南省重点研发计划海南省卫生健康行业科研项目全国名老中医药专家传承工作室建设项目国家中医药局林天东传承工作室建设项目(第四届)

ZDYF2021SHFZ22521A200410国中医药人教函[2022]76号国中医药办人教函[2022]245号

2024

10.3969/j.issn.1673-9701.2024.23.018

中国现代医生
中国医学科学院

中国现代医生

影响因子：1.571
ISSN：1673-9701
年,卷(期)：2024.62(23)
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