目的 分析治疗心悸的组方规律及核心药物组合的作用靶点和通路.方法 收集2023年3月至2024年3月李亚平治疗心悸的处方,对药物的性、味、归经和功效进行频次统计,利用SPSS Modeler 18.0和SPSS 26.0软件进行药物的Apriori算法、关联规则及聚类分析.检索核心药物成分及疾病靶点,对其治疗心悸作用靶点进行基因本体(gene ontology,GO)和京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)分析.结果 共收集中药处方220首,涉及中药192味,累计用药频次3978次,高频药物18味.治疗心悸用药以补虚药、安神药、活血化瘀药为主;药性以温、寒、平为主,药味以甘、苦、辛为主,归经以心、肝、脾经居多.关联规则分析显示,当归、丹参、甘草、麦冬和黄芪等为核心药物.聚类分析显示有3个聚类组合.网络药理学分析显示,药物组合与疾病交集靶点共181个.KEGG分析显示,核心药物治疗心悸主要涉及磷脂酰肌醇3激酶/蛋白激酶B、缺氧诱导因子-1、丝裂原活化蛋白激酶、白细胞介素-17等信号通路,GO分析显示,共包括1000条GO途径,其中生物过程760条,细胞组分93条,分子功能147条.结论 李亚平治疗心悸主张益气通阳、化瘀祛浊、通络安神,强调"双心同调",心肝同治,兼顾脾胃,核心药物组合可通过多成分、多靶点、多作用途径干预心悸病程,对临床心悸的治疗具有重要意义.
Analysis of medication patterns for palpitation based on data mining and network pharmacology
Objective To analyze medication patterns and the targets and pathways of core drug combinations in treatment of palpitation.Methods The prescriptions of Li Yaping for treatment of palpitation from March 2023 to March 2024 were collected,and frequency counts of drugs'nature and flavour,channel tropism,and efficacy were performed.Apriori algorithm,association rules,and clustering analysis were carried out using SPSS Modeler 18.0 and SPSS 26.0.The core drugs and disease targets were searched,and gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis were performed on the targets of their therapeutic action for palpitation.Results A total of 220 prescriptions were collected,involving 192 flavors of traditional Chinese medicines,with a cumulative medication frequency of 3978 times,and 18 flavors of high-frequency medicines.The medicines were mainly tonics,sedative,and promoting blood circulation for removing blood stasis.The distribution of medicinal properties were mainly warm,cold and flat.The medicinal flavors were mainly sweet,bitter and pungent,and channel tropism were mostly heart,liver and spleen channel.Association rule analysis showed that Radix Angelicae Sinensis,Radix et Rhizoma Salviae Miltiorrhizae,Radix et Rhizoma Glycyrrhizae,Radix Ophiopogonis,and Radix Astragali were the core drugs.Cluster analysis showed that there was 3 cluster combinations.In the network pharmacology part,there were 181 targets intersected by drug combinations and diseases.KEGG analysis showed that the core drugs for palpitation mainly involved signaling pathways such as phosphoinositide 3-kinase/protein kinase B,hypoxia-inducible factor-1,mitogen-activated protein kinase,interleukin-17,etc.GO analysis obtained 1000 GO pathways,of which 760 were biological processes,93 were cellular components,and 147 were molecular functions.Conclusion In the treatment of palpitation,Li Yaping advocates benefiting qi and promoting yang,removing blood stasis and eliminating turbidity,and tranquilizing the mind,emphasizing the"two hearts in the same adjustment",and treating the heart and liver at the same time,taking into account the spleen and stomach,and the combination of core medicines can intervene in the course of palpitation through multi-components,multi-targets,and multi-pathways,which is of great significance for the treatment of palpitation in the clinical setting.
万方数据
维普
