Objective To investigate the effect of the differential distribution of three platelet glycoprotein(GP)specific antibodies(anti-GPⅠb/Ⅸ,GP Ⅱb/Ⅲa and GPⅠa/Ⅱa antibodies)on the efficacy of first-line treatment in children with primary immune thrombocytopenia(ITP).Methods A retrospective analysis was performed on 54 children with ITP who were hospitalized in Mianyang Central Hospital from December 2019 to December 2023.According to the antibody test results,they were divided into:group A1(anti-GPⅠb/Ⅸ antibody positive,18 cases)and group A2(anti-GPⅠb/Ⅸ antibody negative,36 cases),group B1(anti-GP Ⅱb/Ⅲ a antibody positive,30 cases)and group B2(anti-GP Ⅱb/Ⅲ a antibody negative,24 cases),group C1(anti-GPⅠa/Ⅱa antibody positive,16 cases)and group C2(anti-GPⅠa/Ⅱa antibody negative,38 cases).All patients were given standard first-line treatment.The relationship between the distribution of antibodies and the trend of counting of platelet(PLT)after treatment was analyzed.Results After treatment,PLT counts in all groups increased significantly over time(P＜0.05).The PLT count in group Al was significantly lower than that in group A2 at 24h,72h and 7days after treatment(P＜0.05).There was no significant difference in PLT count between group B1 and group B2 at different time points(P＞0.05).At 7 days after treatment,the PLT count in group C1 was significantly lower than that in group C2(P＜0.05).At one month after treatment,the efficacy of children in group A1 and group C1 were significantly lower than those in group A2 and group C2,respectively(P＜0.05).There was no significant difference in the efficacy between group B1 and group B2(P=0.081).Conclusion There are differences in the efficacy of ITP children with different distribution of antibodies after first-line treatment,the efficacy of children with positive anti-GPⅠb/Ⅸ antibody and anti-GPⅠa/Ⅱ a antibody are worse,and the efficacy of children with positive and negative anti-GP Ⅱb/Ⅲ a antibody is not different.
关键词
原发免疫性血小板减少症/血小板糖蛋白特异性抗体/儿童/血小板计数
Key words
Primary immune thrombocytopenia/Platelet glycoprotein specific antibody/Child/Platelet count
维普
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