Influence of differential distribution of platelet glycoprotein antibodies on clinical efficacy of primary immune thrombocytopenia in children
Objective To investigate the effect of the differential distribution of three platelet glycoprotein(GP)specific antibodies(anti-GPⅠb/Ⅸ,GP Ⅱb/Ⅲa and GPⅠa/Ⅱa antibodies)on the efficacy of first-line treatment in children with primary immune thrombocytopenia(ITP).Methods A retrospective analysis was performed on 54 children with ITP who were hospitalized in Mianyang Central Hospital from December 2019 to December 2023.According to the antibody test results,they were divided into:group A1(anti-GPⅠb/Ⅸ antibody positive,18 cases)and group A2(anti-GPⅠb/Ⅸ antibody negative,36 cases),group B1(anti-GP Ⅱb/Ⅲ a antibody positive,30 cases)and group B2(anti-GP Ⅱb/Ⅲ a antibody negative,24 cases),group C1(anti-GPⅠa/Ⅱa antibody positive,16 cases)and group C2(anti-GPⅠa/Ⅱa antibody negative,38 cases).All patients were given standard first-line treatment.The relationship between the distribution of antibodies and the trend of counting of platelet(PLT)after treatment was analyzed.Results After treatment,PLT counts in all groups increased significantly over time(P＜0.05).The PLT count in group Al was significantly lower than that in group A2 at 24h,72h and 7days after treatment(P＜0.05).There was no significant difference in PLT count between group B1 and group B2 at different time points(P＞0.05).At 7 days after treatment,the PLT count in group C1 was significantly lower than that in group C2(P＜0.05).At one month after treatment,the efficacy of children in group A1 and group C1 were significantly lower than those in group A2 and group C2,respectively(P＜0.05).There was no significant difference in the efficacy between group B1 and group B2(P=0.081).Conclusion There are differences in the efficacy of ITP children with different distribution of antibodies after first-line treatment,the efficacy of children with positive anti-GPⅠb/Ⅸ antibody and anti-GPⅠa/Ⅱ a antibody are worse,and the efficacy of children with positive and negative anti-GP Ⅱb/Ⅲ a antibody is not different.
Primary immune thrombocytopeniaPlatelet glycoprotein specific antibodyChildPlatelet count
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维普
